Surely there is a Loupis support group in the USA.
All of the hand , arm & foot braces she wears come from the USA.
If your wife has not had one, get a full hormone analysis done, and by full I mean full. Costed around $ 6,000 down here but I would happily pay that amount again & again for the benefits she derrived from the results.
SWMBO had one done when she was in hospital for extreme vertigo.
The principle problem ended up being the contraceptive she had been using for 20 years.
After treatment she got a lot better, put on some weight so a fart no longer blew her out of bed.
The Loupis society down here is fantastic because just like your other 1/2 when she bursts into tears from the pain in opening out her hand she got treated as a hypochondriac as well and to top it off got accused of being a drug addict trying to get perscription drugs for pleasure.
Every one seems to be different and yes some things work full time while others look like they will be great, then loose effect very quickly.
She bought a wax bath and that is the only thing that has always made things better but even now the relief from it is diminishing.
She found that constant movement which causes almost permanent pain worked a lot better than not moving then being in intense pain when she had to do things like grab a knife or wrap the fingers around a steering wheel.
Sorry to hear your wife has become bad enough to require morphine