I have been working on 2 -cycle engines since they came out in yard tools. The factory L, H, and LA settings, i.e. screw turns from closed are a beginning point to get your engine running and keep it running. Adjust the idle (L) screw first. If the engine dies, adjust the LA (idle speed) until the engine will run without stalling. Then adjust the L screw until it runs smoothly. Turn the LA in until the engine runs at a desirable idle speed. If the idle is not smooth, adjust L a little until it is smooth. If the idle speed is correct and the engine idles well, all the powered machinery will be stopped. That is stopped, no creep or movement. The machine is safe. Now open the throttle to full power. The factory setting will maintain the right rpm. Only adjust the H screw if the engine is not smooth. If the engine is rich, it will run rough and may smoke - turn the H in. If the engine is running too lean it will stumble and may stop when the throttle is opened quickly. Adjust for smooth operation. Remember the factory settings are a place to start. Air density due to altitude does require re-adjustment.
Item 2. If the engine runs well at first but gets worse over time when you use it next time and needs to be re-adjusted, check this first. If the engine runs well when the tank is full, check the tank when the roughness starts. If the fuel level is down, the problem may be a cracked fuel line in the tank. The fuel pump will suck fuel through the crack when the tanks is full, but when the fuel level goes down and the crack is exposed to the air, the fuel pump will suck in some air and the engine will run rough. Changing the fuel line is an easy fix. Good Luck
Item 2. If the engine runs well at first but gets worse over time when you use it next time and needs to be re-adjusted, check this first. If the engine runs well when the tank is full, check the tank when the roughness starts. If the fuel level is down, the problem may be a cracked fuel line in the tank. The fuel pump will suck fuel through the crack when the tanks is full, but when the fuel level goes down and the crack is exposed to the air, the fuel pump will suck in some air and the engine will run rough. Changing the fuel line is an easy fix. Good Luck